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Recipient Outcomes Following Transplantation of Allografts From Live Kidney Donors Who Subsequently Developed End-Stage Renal Disease

The American Journal of Transplantation dedicated their December issue to organ donors who gave the gift of life to over 13,066 people this year (as of 11/18/2016).

At ERGOT, we care about the health and well being of live donors. In Recipient Outcomes Following Transplantation of Allografts From Live Kidney Donors Who Subsequently Developed End-Stage Renal Disease, data shows that preexisting kidney disease might be one mechanism underlying live donor end-stage renal disease.

Transplant Titan. Renaissance Man.

The Fall 2016 issue of Hopkins Medicine calls him the “Transplant Titan.” We just call him Dorry, and he’s leading a dynamic and life-saving campaign to make organs available to those who need them.

A Virtual Space for Children with Liver Disease and Their Families

ERGOT’s Douglas Mogul, MD MPH led a team to create the new Facebook application: Liver Space. Mogul wanted to create a community that connected pediatric liver disease patients and their families and provided them with useful information.

“It’s designed to strengthen online communities, serving as a bridge to health care providers and a portal for conducting research,” Mogul told Sarah Richards at Johns Hopkins.

Mogul is currently in talks about creating a similar site for patients with kidney disease.

How We Did the First HIV-Positive to HIV-Positive Transplant in the US: The Policy & the Science

Join us as ERGOT founder and director Dorry Segev, MD PhD leads a discussion with student speakers Ashton Shaffer, Jessica Ruck, and Alyssa Martin about the first HIV-Positive to HIV-Positive in the United States.

The talk will take place at 4:30pm on Monday, November 21 in Miller Research Building on the ground floor.

Doctors Use Hepatitis C-Infected Kidneys to Save Lives

Drs. Niraj Desai and Christine Durand talk with CBS Baltimore about transplanting patients with hepatitis C-infected kidneys. The Johns Hopkins trial includes 10 patients from Baltimore, 5 of which have already been transplanted.

This is now a viable option now the hepatitis C is curable. This has the potential to shrink the transplant waitlist which is currently over 200,000 people in the US, 82-percent of whom need kidneys.

“If we had enough organs, we wouldn’t do this,” says Dr. Desai.

Interview: HIV and Transplantation: New Reasons for HOPE

Three years after the HOPE Act was signed by President Obama, and three months after the first HIV-positive to HIV-positive transplant in the US, Dr. Dorry Segev sits down with the Journal of the American Medical Association to discuss how far transplantation has come since the 1980s.

You can read the full interview here.

Lab Publications in AJT

Lab members Allan Massie, PhD and Sunjae Bae, KMD MPH had their papers published in the July issue of American Journal of Transplantation.

 

A Risk Index for Living Donor Kidney Transplantation (pages 2077–2084)
A. B. Massie, J. Leanza, L. M. Fahmy, E. K. H. Chow, N. M. Desai, X. Luo, E. A. King, M. G. Bowring and D. L. Segev

This study proposes a risk index for living donor kidney transplant recipients, the LKDPI, which quantifies the risk of graft loss on the same scale as the KDPI. See editorial on page 1951 from Schold and Kaplan.

 

Changes in Discard Rate After the Introduction of the Kidney Donor Profile Index (KDPI) (pages 2202–2207)
S. Bae, A. B. Massie, X. Luo, S. Anjum, N. M. Desai and D. L. Segev

Providing the Kidney Donor Profile Index (KDPI) with deceased donor kidney offers is associated with increased discards of standard criteria donor kidneys with KDPI > 85, a subgroup where the old standard/extended criteria donor designation and the new KDPI scoring deliver opposing messages, suggesting the possibility of a labeling effect.

First HIV-positive to HIV-positive transplant in the US

After six years of starting the campaign in Washington D.C. and after three years of passing the HOPE Act, Johns Hopkins performs the first HIV-positive to HIV-positive transplant in the US. ERGOT’s own Dr. Dorry Segev took part in front-running for the change in legislation that now allows the once illegal practice of donating and transplanting HIV-positive organs.

Photo credit to KRISTOPHER RADDER/U.S. Navy

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